祝福
4-氨基吡啶
前庭系统
医学
2-氨基吡啶
听力学
心理学
重症监护医学
内科学
神学
哲学
化学
钾通道
药物化学
作者
Roswitha Beck,Lisa M. Gunther,Guoming Xiong,Heidrun Potschka,Guido Böning,Peter Bartenstein,Thomas Brandt,Klaus Jahn,Marianne Dieterich,Michael Strupp,Christian la Fougère,Andreas Zwergal
标识
DOI:10.1016/j.expneurol.2014.08.013
摘要
Early symptomatic treatment of acute unilateral vestibulopathy is thought to impede the course of ensuing central vestibular compensation (VC). Despite the great clinical importance of this hypothesis there is no experimental evidence of its validity. The present study addressed this question by investigating the direct effect of 4-aminopyridine (4-AP) on ocular motor and postural symptoms in acute unilateral vestibulopathy as well as its long-term consequences for VC in a rat model of chemical unilateral labyrinthectomy (UL). After UL, one group of Sprague–Dawley rats was treated with 4-AP p.o. (1 mg/kg/day), another with 0.9% NaCl solution p.o. for 3 days. Behavioural testing for symptoms of vestibular tone imbalance was done 1 day before and 1, 2, 3, 5, 7, 9, 15, 21, and 30 days after UL. In addition, sequential whole-brain [18F]-FDG-μPET was performed before and 1, 3, 7, 15, and 30 days after UL to examine and visualize 4-AP-induced modulation of VC. Administration of 4-AP on days 1–3 significantly improved postural imbalance 2 h after administration compared to that in controls. This effect was only transient. Remarkably, the 4-AP group had a prolonged and impaired course of postural compensation compared to that of controls. The μPET revealed a significant increase of regional cerebral glucose metabolism (rCGM) in the vestibulocerebellum 2 h after administration of 4-AP. However, the 4-AP group exhibited a persistent asymmetry of rCGM after day 3 in the vestibular nuclei and posterolateral thalami. In conclusion, this study confirms the hypothesis that early pharmacological abatement of vestibular symptoms impedes VC.
科研通智能强力驱动
Strongly Powered by AbleSci AI