硒
化学
硫醇
纳米颗粒
荧光
谷胱甘肽
钌
生物物理学
癌细胞
胶体金
细胞毒性
体内分布
姜黄素
作者
Dongdong Sun,Yanan Liu,Qianqian Yu,Xiuying Qin,Licong Yang,Yanhui Zhou,Lanmei Chen,Jie Liu
出处
期刊:Biomaterials
[Elsevier]
日期:2014-02-01
卷期号:35 (5): 1572-1583
被引量:91
标识
DOI:10.1016/j.biomaterials.2013.11.007
摘要
Here we reported the high tumor targeting efficacy of luminescent Ru(II)-thiols protected selenium nanoparticles (Ru-MUA@Se). We have shown that a dual-target inhibitor Ru-MUA@Se directly suppress the tumor growth but also block blood-vessel growth. We also determined that the nanoparticles entered the cells via clathrin-mediated endocytosis pathway. In a xenograft HepG2 tumor model, we found that Ru-MUA@Se effectively inhibited tumor angiogenesis and suppressed tumor growth with low side effects using metronomic chemotherapy with Ru-MUA@Se. In vivo investigation of nanoparticles on nude mice bearing HepG2 cancer xenografts confirmed that Ru-MUA@Se nanoparticles possessed high tumor-targeted fluorescence imaging, exhibited enhanced antitumor efficacy and decreased systemic toxicity. Moreover, Ru-MUA@Se not only significantly induced dose-dependent disruption of mitochondrial membrane potential in HepG2 cells after 24 h treatment, but it also enhanced reactive oxygen species (ROS) generation. Our results suggest that the potential application of these Ru-MUA@Se nanoparticles in targeting cancer imaging and chemotherapy.
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