普鲁士蓝
光热治疗
材料科学
阿霉素
体内
纳米颗粒
纳米技术
癌细胞
红细胞
生物物理学
癌症
化疗
药物输送
化学
医学
免疫学
外科
内科学
生物
生物技术
电化学
物理化学
电极
作者
Wansong Chen,Ke Zeng,Hong Liu,Jun Ouyang,Liqiang Wang,Ying Li,Hao Wang,Deng Liu,You‐Nian Liu
标识
DOI:10.1002/adfm.201605795
摘要
Nanodrug‐based cancer therapy has been actively developed in the past decades. The main challenges faced by nanodrugs include poor drug loading capacity, rapid clearance from blood circulation, and low antitumor efficiency with high risk of recurrence. In this work, red blood cell (RBC) membrane camouflaged hollow mesoporous Prussian blue nanoparticles (HMPB@RBC NPs) are fabricated for combination therapy of cancer. The stability, immune evading capacity, and blood retention time of HMPB@RBC NPs are significantly enhanced compared with those of bare HMPB NPs. Doxorubicin (DOX), as a model drug is encapsulated within HMPB@RBC NPs with loading capacity up to 130% in weight. In addition, DOX loaded HMPB@RBC NPs show pH‐/photoresponsive release. The in vivo studies demonstrate the outstanding performance of DOX@HMPB@RBC NPs in synergistic photothermal‐/chemotherapy of cancer.
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