体内
细胞毒性
赫拉
体外
酸浆
细胞培养
生物
黑色素瘤
MTT法
癌症研究
分子生物学
化学
生物化学
植物
遗传学
生物技术
作者
Hsüch‐Ching Chiang,S M Jaw,C F Chen,Weijuan Kan
出处
期刊:PubMed
日期:1992-05-01
卷期号:12 (3): 837-43
被引量:32
摘要
Physalin F and physalin D were isolated and characterized from the ethanolic extract of the whole plant of Physalis angulata L. (Solanaceae). Systematic fractionation of the ethanolic extract of the plant led to characterization of physalin F from the fraction PAIV-2 as an active ingredient which showed cytotoxicity in vitro by DEA and MTT assays on 8 cancer cell lines, five human cancer cell lines: HA22T(hepatoma), HeLa(cervix uteri), KB(nasopharynx), Colo-205(colon) and Calu-1(lung); and three animal cancer cell lines: H1477(melanoma), Hep-2(laryngeal) and 8401(glioma). It was found that the anti-hepatoma action is the strongest, and the anti-HeLa is the next. Physalin F also had an antitumor effect in vivo against P388 lymphocytic leukemia in mice whereas physalin D was inactive both in vitro and in vivo.
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