脂肪组织
内科学
内分泌学
瘦素
脂肪细胞
脂肪组织巨噬细胞
肥胖
生物
白色脂肪组织
医学
作者
Lili Tang,Xiao-Han Tang,Xia Li,Haibo Yu,Zhiguo Xie,Xinyuan Liu,Zhiguang Zhou
出处
期刊:Acta Academiae Medicinae Sinicae
日期:2014-12-01
卷期号:36 (6): 614-9
被引量:9
标识
DOI:10.3881/j.issn.1000-503x.2014.06.010
摘要
To investigate the effect of high-fat or high-glucose diet on obesity and visceral adipose tissue in C57BL/6 mice.Four-week-old C57BL/6 mice were allocated into normal diet group,high-fat diet group,and high-glucose diet group according to the random number table until 20 weeks old. Body weight,epididymal adipose tissue weight,blood leptin,fat infiltration in liver,M1/M2 macrophage subtypes,and monocyte chemoattractant protein-1 mRNA in epididymal adipose tissues were measured.Compared with normal diet group,body weight,epididymal adipose tissue weight,and leptin concentration in high fat diet group at 20 weeks were significantly increased (P < 0.05),and oil red O staining showed more prominent adipocyte infiltration in liver in high-fat diet group than those in normal diet and high-glucose diet group. However,no apparent differences were seen in high-glucose diet group at 20 weeks in terms of body weight,epididymal adipose tissue weight and leptin concentration. In high-fat diet group,the macrophages infiltration in epididymal adipose tissue increased with time and the percentage of M2 macrophage decreased in high-fat diet group than that in high-glucose diet group(P<0.05). Compared with normal diet group,monocyte chemoattractant protein-1 mRNA expression increased significantly in high-fat diet group(P<0.05). In high-glucose group,however,no significant differences were discerned (P > 0.05).High-fat diet,rather than 60% high glucose diet,will lead to obesity and macrophage infiltration in adipose tissues.
科研通智能强力驱动
Strongly Powered by AbleSci AI