Correlation analysis of the serum DKK1 level,lung cancer,and its pathological types

Objective To investigate the association between serum Dickkopf 1(DKK1) level,lung cancer,and its pathological types.Methods 101 patients with lung cancer diagnosed by bronchoscopic biopsy or Pathological section,including 55 cases of squamous cell carcinoma,16 cases of adenocarcinoma and 30 cases of small cell lung cancer,and 102 healthy individuals were enrolled in this study.Serum DKK1 and Cyfra21-1 level of all subjects were measured.Difference comparison of measured data among groups was determined by single factor variance analysis.Results Comparing with the control group,the mean level of DKK1 in patients with lung cancer was significantly higher than the samples in the control group(P0.05).There was no significant difference between different histological types of lung cancer(P0.05).The serum level of DKK1 was the highest in squamous cell carcinoma,followed by adenocarcinoma and small cell lung cancer.Conclusion Serum level of DKK1 is related to the lung cancer but not related to its pathological types.