角质层
渗透(战争)
体内
按摩
人体皮肤
纳米颗粒
毒性
生物医学工程
锌
脱皮
材料科学
生物物理学
化学
纳米技术
皮肤病科
医学
病理
生物
生物技术
冶金
替代医学
运筹学
有机化学
遗传学
工程类
作者
Vânia Rodrigues Leite-Silva,David C. Liu,Washington Y. Sanchez,Hauke Studier,Yousuf Mohammed,Amy Holmes,Wolfgang Becker,Jeffrey E. Grice,Heather A. E. Benson,Michael S. Roberts
出处
期刊:Nanomedicine
日期:2016-05-01
卷期号:11 (10): 1193-1205
被引量:48
标识
DOI:10.2217/nnm-2016-0010
摘要
Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (˜75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.
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