Upregulation of toll-like receptor 4 (TLR4)/MD-2 complex in LPS hypersensitive livers in mice

Background: LPS sensitivity in the liver significantly worsens the outcome of gram negative sepsis. MD-2 facilitates the recognition of LPS by Toll-like receptor (TLR4). In this study we investigated the changes in TLR4 and MD-2 levels in LPS sensitive livers.