Potential value and feasibility of N-of-1 randomized controlled trials in research of traditional Chinese medicine

N-of-1 randomized controlled trials(RCT) may be a promising method of evidence-based medicine for the research of traditional Chinese medicine.The idea of individualized treatment reflected by N-of-1 RCT accords with treatment based on syndrome differentiation.This paper investigated into the principles and methods of N-of-1 RCT to explore the feasibility and potential value in the clinical research of traditional Chinese medicine.