Stent as a drug controlled release platform,is an effective means of reducing neointimal hyperplasia by controling drug release and convey.Drug-eluting stent(DES) restenosis may still occur especially when stents are used in complex anatomical and clinical scenarios which indicated that still need to be improved.This article summarizes the relationship in the drug-eluting stent parameters and discuss these parameters play what role in anti-restenosis process and order to provide a reference for reducing restenosis.