Preparation of Mixed Film Microcapsule Contain Clarithromycin

Prepared the mixed film microcapsule by solvent evaporation when clarithromycin is model drug,ethyl cellulose and hydroxypropyl methyl cellulose is membrane materials.Explored the optimumexperimental conditions and investigated into relaxed controlled release property of mixed film microcapsule.The experimental results show that the optimum experimental conditions of preparing the mixed film microcapsule are gained.Conclusions when membrane materials concentration is 3% in dispersed phase,ethyl cellulose/hydroxypropyl methyl cellulose is 6∶1~7∶1,drug dosage is 2∶1~ 3∶1,SDS concentration is 0.1%,PVA concentration is 1.0% in continuous phase and volume ratio of oil/water is 1∶8.