The Side-effects of Olanzapine on Orthostatic Blood Pressure Regulation in Elder Inpatients and The Nursing Measures of Orthostatic Hypotension

Objective To evaluate the adverse effects of olanzapine on orthostatic blood pressure regulation in elder inpatients.Methods 67 elder inpatients with mental disorder were involved and assigned to treatment with olanzapine(5-10mg/d).The blood pressure was measured in lying-position and standing-position respectively pre-and pro-treatment.The delta of systolic blood pressure,diastolic blood pressure were calculated by subtraction of two position,and the prevalence of orthostatic hypotension was observed.Results The delta of systolic blood pressure,diastolic blood pressure during the lying-standing position exchangement were significantly higher after treatment than before treatment(P=0.000,0.009 respectively),the same as the prevalence of orthostatic hypotension(P=0.005).In multivariate analysis,the risk factors for orthostatic hypotension were drug navie(P=0.007)and higher delta of systolic blood pressure(P=0.023)during the position exchangement before treatment.Conclusion Olanzapine can effect the orthostatic blood pressure regulation in elder inpatients and lead to the orthostatic hypotension.We have to observe key population,prevent first,recognize early and handle in time.