According to the structure of stainless steel impeller casting, two kinds of different pouring system have been designed, and the casting process numerical simulation have been conducted with ProCAST software in order to project the foundry defects. Then based on the preliminary simulated results and adopting some improving measures, such as adding a riser and chilling iron etc, the final casting technique of impeller has been determined after simulation analysis at different pouring temperature. The results of trial production has shown that the impeller casting completely has met the requirements of technology.