Protective effect of Yunnan folk medicine Rhodobryum roseum on experimental myocardial ischemia of rat

Object To study the protective effect of Rodobryum roseum (Hedw) Limpr. on acute myocardial ischemia. Methods Rat acute myocardial ischemia models were prepared by ligating their left coronary arteries. Changes of their S-T segment was observed on lead Ⅱ dynamic ECG. Degree of ischemia was assessed by the extent of S-T segment elevation. Lactic dehydrogenase (LDH), creative phosphokinase (CPK), superoxide dismutase (SOD) and malondialdehyde (MDA) were determined at the same time. Results R. roseum can significantly alleviate S-T segment elevation, being most evident at the dose of 2 g/kg (P0.05); at doses of 1 and 2 g/kg myocardic infarct size was reduced (P0.05 and P0.01). Both LDH and CPK were reduced, being more evident for CPK. The drug also increased SOD (P0.05) and lowered MDA (P0.01). Conclusion R. roseum is effective, to a certain degree, for the protection of myocardial ischemia. Such effect may be related to its anti-lipid-peroxidation activity.