Silencing of suppressor of cytokine signaling-1(SOCS1)enhances the therapeutic effect of dendritic cell vaccine in animal model of lung cancer

Although dendritic cells(DC)are the most potent professional antigen-presenting cells to activate the innate and a- daptive immunity against lung cancer,however,on account of the presence of immune escape mechanism,the therapeutic effect of vaccine based on DC is only of limited success in the clinic trails.The major challenge is to find a means to overcome the inhibitory mechanism and to provoke an effective T cell response to antigens expressed by tumor cells,in which improve- ment of the ability in antigen presentation of DC vaccine may he the main point to enhance its therapeutic effect.In the present study,we had adopted the RNA interference(RNAi)technique to inhibit the expression of suppressor of cytokine signaling-1 (SOCS1)in order to silence the effect of SOCS1 of suppressing the activities of antigen presenting ability of DC and thus effi- ciently activating the specific anti-tumor immunity.In this way,the therapeutic effect of vaccine based on DC are effectively enhanced.