To Compare Effects of Shenkangwan or Atorvastatin on Serum inflammatory cytokines in Type 2 Diabetic Patients with early Diabetic Nephropathy

Objective To compare effects of Shenkangwan or Atorvastatin on inflammatory cytokines in type 2 diabetic patients with early diabetic nephropathy(DN),and explore its therapeutic mechanism.Methods 88 cases of DN were randomly divided into the control group (C,n=28),the Atorvastatin treated group (DA,n=30) and the Shenkangwan treated group (DS,n=30). Education course,dietary treatment and conventional hypoglycemic agent were given to three groups,Atorvastatin and Shenkangwan was given additionally to patients in the DA and DS groups respectively.Fasting blood glucose (FBG),Lipids(compose of TC,TG,LDL-C and HDL-C),urine α1-MG,C-reactive protein (CRP),interleukin-6 (IL-6),and tumor necrosis factor-α(TNF-α) were measured Before and after 8 weeks'treatment. Results After treatment,the FBG of DS group decreased remarkably compared with group C and DA (P0.05). The Serum TC,TG,and LDL-C of DA group were dropped and HDL-C elevated obviously compared with group C and DS(P0.01).At the same time,the levels of urine α1-MG ,CRP,IL-6 and TNF-α decreased significantly in the group DA and DS respectively compared with group C(P0.01),the effect showed remarkable in the DS group than that in the DA group (P0.05).Conclusion Both Shenkangwan and Atorvastatin can reduce the DN patients' α1-MG in urine and serum levels of inflammatory cytokines,have protective effect of the kidney not dependent on hypoglycemic and lipid-lowering,the effect of the former is more obvious.