纳米颗粒
药物输送
聚合物
纳米技术
生物物理学
化学
毒品携带者
组合化学
材料科学
有机化学
生物
作者
Nayeleh Deirram,Changhe Zhang,Sarah S. Kermaniyan,Angus P. R. Johnston,Georgina K. Such
标识
DOI:10.1002/marc.201800917
摘要
Abstract Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli‐responsive nanoparticles because nanoparticles are internalized into cells via vesicles that are acidified. Additionally, the tumor microenvironment is known to have a lower pH than the surrounding tissue. In this review, different strategies to design pH‐responsive nanoparticles are discussed, focusing on the use of charge‐shifting polymers, acid labile linkages, and crosslinking.
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