药物输送
普鲁士蓝
体内
阿霉素
双金属片
癌细胞
材料科学
纳米技术
细胞毒性
生物物理学
体外
核化学
化学
癌症
金属
生物化学
有机化学
化疗
外科
医学
物理化学
生物技术
内科学
生物
电化学
电极
作者
Qiaojuan Jia,Fangfang Su,Zhenzhen Li,Xiaoyu Huang,Linghao He,Minghua Wang,Shaoming Fang,Nan Zhou
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2019-05-02
卷期号:2 (5): 2143-2154
被引量:16
标识
DOI:10.1021/acsabm.9b00129
摘要
Owning to the improved ability of selectivity and penetration toward cancer cells, drug delivery systems (DDSs) play essential roles in chemotherapy for solid tumors. Herein, a series of bimetallic MnFe Prussian blue analogues (PBAs) with a tunable nanostructure was prepared by using sodium citrate (SC) as a structure regulator (represented by MnFe-PBA-SC). An advanced targeted drug delivery system was obtained by adding folic acid (FA) to the preparation system of MnFe-PBA-SC nanospheres (denoted as MnFe-PBA-SC-FA). The shape of pure MnFe PBA was changed from a typical nanocube to a hollow nanosphere when adding SC, leading to the formation of the core-shell nanospheres of the MnFe-PBA-SC-FA composite. The hollow nanostructures and intrinsic cavities in PBA can carry large amounts of doxorubicin (DOX), showing a high loading efficiency of MnFe-PBA-SC1.0-FA (91.8%), which was higher than that in MnFe-PBA-SC0.5 (63.2%). Additionally, the series of MnFe-PBAs showed pH-responsive drug release behaviors. A cell viability assay illustrated no remarkable cytotoxicity of MnFe-PBA-SC-FA against human breast cancer cells, Michigan Cancer Foundation-7 (MCF-7) cells, for 24 h. Confocal laser scanning showed that the MnFe-PBA-SC1.0-FA/DOX system significantly entered FA receptor-expressing MCF-7 cells in vitro and in vivo, while an increased DOX release was observed in the cytoplasm of the MCF-7 cells. In consequence, this novel anticancer delivery system based on bimetallic PBAs can be potentially applied to drug delivery.
科研通智能强力驱动
Strongly Powered by AbleSci AI