适体
锆
复合数
电化学
材料科学
卟啉
石墨烯
纳米复合材料
检出限
双金属
电化学气体传感器
介电谱
电极
纳米技术
堆积
化学工程
化学
复合材料
色谱法
有机化学
物理化学
冶金
生物
遗传学
工程类
作者
Hongkai Li,Hai-Lin Ye,Xiaoxue Zhao,Xiaolong Sun,Qianqian Zhu,Zhang-Ye Han,Rongrong Yuan,Hongming He
标识
DOI:10.1016/j.cclet.2021.02.042
摘要
More and more attentions have been focused on design and synthesis of novel metal-organic framework/graphene oxide (MOF/GO) composites with unique performance. Zirconium-porphyrin MOF (PCN-222) is in-situ synthesis with the existence of GO with −COOH group to artfully fabricate a PCN-222/GO composite. This composite can be employed as functional material to modify the working electrode. Thanks to excellent electrical conductivity of GO, abundant mesoporous channels and numerous Zr(IV) metal sites of PCN-222, this composite can immobilize a large amount of aptamer through strong π-π stacking interaction and high affinity between phosphate group of aptamer and Zr(IV) site of PCN-222 simultaneously. Hence, an ultra-sensitive electrochemical aptasensor based on PCN-222/GO composite can quantificationally detect trace chloramphenicol with limit of detection of 7.04 pg/mL (21.79 pmol/L) from 0.01 ng/mL to 50 ng/mL by electrochemical impedance spectroscopy even in real samples. Meanwhile, this fabricated aptasensor reveals good repeatability, outstanding selectivity and preferable long-term storage. This research provides a useful approach to construct MOF/GO composites for fabricating electrochemical aptasensors in the electrochemical detection field.
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