Mechanochemistry for sustainable and efficient dehydrogenation/hydrogenation

Hydrogenation and dehydrogenation reactions are one of the pillars of the chemical industry, with applications from bulk chemicals to pharmaceuticals manufacturing. The ability to selectively add hydrogen across double and (or) triple bonds is key in the chemist’s toolbox and the enabling component in the development of sustainable processes. Traditional solution-based approaches to these reactions are tainted by significant consumption of energy and production of solvent waste. This review highlights the development and applications of recently emerged solvent-free approaches to conduct the hydrogenation of organic molecules using mechanochemistry, i.e., chemical transformations induced or sustained by mechanical force. In particular, we will show mechanochemical techniques such as ball-milling enabled catalytic or stoichiometric metal-mediated hydrogenation and dehydrogenation reactions that are simple, fast, and conducted under significantly milder conditions compared with traditional solution routes. Importantly, we highlight the current challenges and opportunities in this field, while also identifying exciting cases in which mechanochemical hydrogenation strategies lead to new, unique targets and reactivity.