Gastro-retentive drug delivery systems: a recent update on clinical pertinence and drug delivery

Gastro-retentive drug delivery systems are some of the best technologies delivered through oral route. These mainly came into picture for their effective local action in the GI region, specifically for the drugs with narrow absorption window. In the recent decades, several technologies have evolved showing different mechanisms for retaining the drug in GI region for longer duration with increased bioavailability. Floatable, mucoadhesive, swelable, magnetic, nanofibrous, high-density, and expandable systems have been investigated extensively as the potential gastro-retentive strategies. The advances in the technologies studied, their clinical pertinence, and methods of drug delivery are described in this review with their immense future utilities. Their entry into the pharmaceutical market is a huge matter to look into as most of the studied strategies are facing problems and hence are underrated to overcome the clinical trials. Their success in the clinical trials are enormously required for gaining their access into the pharmaceutical market. Selection of the right technology for the right purpose through the right mechanism of action is to be done for obtaining the system with desired activity.