医学
慢性肝炎
FOXP3型
替诺福韦
外周血单个核细胞
CTLA-4号机组
免疫学
胃肠病学
内科学
病毒载量
人类免疫缺陷病毒(HIV)
免疫系统
T细胞
病毒
生物
体外
生物化学
作者
Hyosun Cho,Hyojeung Kang,Ji Young Kim,Hee-Young Kim,Chang W Kim
出处
期刊:Future Virology
[Future Medicine]
日期:2020-04-01
卷期号:15 (4): 235-244
被引量:1
标识
DOI:10.2217/fvl-2019-0128
摘要
Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials & methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results & conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.
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