Iron accumulation negatively regulates skeletal muscle myogenesis

Background: Skeletal muscle mass is defined by the homeostatic coordination of muscle degeneration and regeneration under various pathophysiological conditions. We have previously reported that iron accumulation induces skeletal muscle atrophy via the ubiquitin-ligase dependent pathway. However, the actionof iron on muscle myogenesis has remained unclear. In the present study, we investigated the effect of iron on skeletal muscle myogenesis.