医学
病态的
V600E型
甲状腺癌
内科学
胃肠病学
甲状腺乳突癌
甲状腺炎
临床意义
回顾性队列研究
甲状腺切除术
甲状腺
病理
突变
基因
生物
生物化学
作者
Chao Shi,Yan Ping Guo,Y C Lyu,Z A B Y S Nanding,Wen Gao,Tiefeng Shi,Hailong Qin,S Y Liu
出处
期刊:PubMed
[National Institutes of Health]
日期:2017-05-23
卷期号:39 (5): 361-366
被引量:4
标识
DOI:10.3760/cma.j.issn.0253-3766.2017.05.008
摘要
Extrathyroid invasion, lymph node metastases and BRAF V600E gene mutation are the high risk factors of recurrent PTMC. The same treatment strategy should be considered for PTMC with coexistent high risk factors as that for larger PTC. For PTMC with BRAF V600E gene mutation, earlier surgical treatment is suggested. PTMC patients with BRAF V600E gene mutation and high cell subtype are suggested to undergo total thyroidectomy for the first operation in order to reduce the potential risk of recurrence.
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