卵巢癌
间充质干细胞
浆液性液体
重编程
癌症研究
生物
雅普1
河马信号通路
颗粒细胞
癌症
生物信息学
肿瘤科
细胞
病理
医学
卵泡期
内分泌学
细胞生物学
效应器
转录因子
遗传学
基因
作者
Xiaozhen Lv,Chunbo He,Cong Huang,Guohua Hua,Xingcheng Chen,Barbara K. Timm,Victoria M. Maclin,Abigail A. Haggerty,Shelly K. Aust,Denae M. Golden,Bhavana J. Davé,Yun An Tseng,Li Chen,Hongbo Wang,Peichao Chen,David Klinkebiel,Adam R. Karpf,Jixin Dong,Ronny Drapkin,Bo R. Rueda,John S. Davis,Cheng Wang
标识
DOI:10.1016/j.scib.2020.03.040
摘要
Understanding the cell-of-origin of ovarian high grade serous cancer (HGSC) is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological cancer. Recently, a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS studies. The cell-of-origin of this subtype of ovarian cancer is unknown. While pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology, we unexpectedly found that the Yes-associated protein 1 (YAP1), the major effector of the Hippo signaling pathway, induced dedifferentiation and reprogramming of the ovarian granulosa cells, a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity, leading to the development of high grade ovarian cancer with serous features. Our research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features.
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