芳香烃受体
免疫系统
多酚
功能(生物学)
调节器
生物
免疫
化学
细胞生物学
生物化学
免疫学
转录因子
抗氧化剂
基因
作者
Jeffry S. Tang,Alissa Cait,Yanyan Li,Helena Abolins-Thompson,Katie Gell,Patries M. Herst,David O’Sullivan,Olivier Gasser
标识
DOI:10.1021/acs.jafc.1c02095
摘要
The ligand-activated aryl hydrocarbon receptor (AhR) is an important molecular regulator of immune function, whose activity can be modulated by dietary glucosinolate- and tryptophan-derived metabolites. In contrast, the potential use of polyphenols as dietary regulators of AhR-dependent immunity remains unclear. In this perspective, we discuss how cellular metabolism may alter the net effect of polyphenols on AhR, thus potentially reconciling some of the conflicting observations reported in the literature. We further provide a methodological roadmap, across the fields of immunology, metabolomics, and gut microbial ecology, to explore the potential effects of polyphenol-rich diets on AhR-regulated immune function in humans.
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