RETRACTED ARTICLE: Two mixed-ligand transition metal coordination polymers: crystal structures and prevention effect on chronic obstructive pulmonary disease

In the current study, via applying the mixed ligand approach, two new transition metal coordination polymers (CPs) with the chemical formulae of [Zn(OBPB)(tfbdc)]n (1) and {[Cd(OBPB)(tfbdc)(H2O)]·DMF}n (2), were hydrothermally synthesized using the self-assembly of the "V-shape" OBPB ligand (1,1'-(oxybis(4,1-phenylene))bis(1H-imidazole)) and the H2tfbdc ligand (2,3,5,6-tetrafluorobenzene-1,4-dicarboxylic acid) with Zn/Cd metal salts. Furthermore, the treatment activity of compounds 1 and 2 against chronic obstructive pulmonary disease (COPD) was evaluated and the related mechanism was explored at the same time. Firstly, the content of the INF-γ released from the respiratory tract was evaluated with ELISA detection kit. Besides, the real time RT-PCR was performed in this study to measure the expression levels of the ampk and stat-1 in the respiratory tract endothelial cells.