淋病奈瑟菌
淋病
环丙沙星
微生物学
奈瑟菌科
生物
抗生素耐药性
奈瑟菌
抗生素
医学
病毒学
细菌
遗传学
人类免疫缺陷病毒(HIV)
作者
Darren Y. J. Lee,M Ashcroft,Eric P F Chow,Michelle Sait,Vesna De Petra,Marlene Tschaepe,Sigrid Lange,George Taiaroa,Catriona S Bradshaw,David M. Whiley,Christopher K Fairley,Benjamin P Howden,Marcus Y Chen,Shivani Pasricha,Deborah A Williamson
摘要
Resistance-guided therapy (RGT) for gonorrhea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Aptima Combo 2 assay, the ResistancePlus GC assay demonstrated 94.8% sensitivity and 100.0% specificity for Neisseria gonorrhoeae detection. Of the 379 concordant N. gonorrhoeae-positive samples, 86.8% were found to possess the gyrA S91F mutation, which was highly predictive for ciprofloxacin resistance and stable across 3,144 publicly available N. gonorrhoeae genomes. Our work supports the feasibility of implementing RGT for gonorrhea into routine molecular workflows.
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