医学
慢性阻塞性肺病
内科学
通风(建筑)
心脏病学
无创通气
麻醉
机械通风
肺功能测试
内皮功能障碍
作者
Alessandro Domingues Heubel,Erika Zavaglia Kabbach,Nathany Souza Schafauser,Shane A. Phillips,Valéria Amorim Pires Di Lorenzo,Audrey Borghi Silva,Renata Gonçalves Mendes
标识
DOI:10.1016/j.rmed.2021.106389
摘要
Abstract Purpose Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD Conclusion NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response.
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