Novel conjugated small molecule-based nanoparticles for NIR-II photothermal antibacterial therapy

Single organic small molecule-based nanoparticles (CNPs) with strong responses within the NIR-II (1000-1350 nm) bio-window were prepared, and successfully applied as a highly efficient photothermal antibacterial agent for the first time. CNPs exhibit an outstanding bacteria inhibition efficiency of almost 100% against Staphylococcus aureus (S. aureus) with a high photothermal conversion efficiency (PTCE) of circa 49% under NIR-II laser irradiation (1064 nm) for 8 min.