光热治疗
生物相容性
光热效应
纳米技术
纳米复合材料
纳米颗粒
抗菌活性
化学
体内
材料科学
体外
细菌
生物化学
生物技术
生物
遗传学
有机化学
作者
Ting Du,Jiangli Cao,Zehui Xiao,Jiaqi Liu,Lifei Wei,Chunqiao Li,Jingbo Jiao,Zhiyong Song,Jifeng Liu,Xinjun Du,Shuo Wang
标识
DOI:10.1186/s12951-022-01535-1
摘要
Abstract Building a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for precise bacterial elimination. Herein, a nanocomposite NiO NPs@AuNPs@Van (NAV) for selective MRSA removal was constructed by electrostatic self-assembly of highly photothermal magnetic NiO NPs and vancomycin (Van)-modified gold nanoparticles (AuNPs). In the presence of MRSA and under NIR irradiation, Van-mediated AuNPs can self-aggregate on MRSA surface, generating photothermal effect in situ and killing 99.6% MRSA in conjunction with magnetic NiO NPs. Additionally, the photothermal efficiency can be improved by magnetic enrichment due to the excellent magnetism of NAV, thereby enhancing the bactericidal effect at a lower experimental dose. In vitro antibacterial experiments and full-thickness skin wound healing test demonstrated that this combination therapy could effectively accelerate wound healing in MRSA-infected mice, increase collagen coverage, reduce IL-6 and TNF-α content, and upregulate VEGF expression. Biological safety experiments confirmed that NAV has good biocompatibility in vivo and in vitro. Overall, this work reveals a new type of nanocomposite with enhanced photothermal antibacterial activity as a potential nano-antibacterial agent for treating bacteria-infected wounds.
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