失智症
额颞叶变性
神经科学
生物
胶质增生
病理
丘脑
痴呆
医学
疾病
作者
Emma Gerrits,Lucia Giannini,Nieske Brouwer,Shamiram Melhem,Danielle Seilhean,Isabelle Le Ber,Alwin Kamermans,Gijs Kooij,Helga E. de Vries,Erik Boddeke,Harro Seelaar,John C. van Swieten,Bart J. L. Eggen
标识
DOI:10.1038/s41593-022-01124-3
摘要
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the progranulin gene (GRN) cause autosomal-dominant FTD (FTD-GRN), associated with TDP-43 inclusions, neuronal loss, axonal degeneration and gliosis, but FTD-GRN pathogenesis is largely unresolved. Here we report single-nucleus RNA sequencing of microglia, astrocytes and the neurovasculature from frontal, temporal and occipital cortical tissue from control and FTD-GRN brains. We show that fibroblast and mesenchymal cell numbers were enriched in FTD-GRN, and we identified disease-associated subtypes of astrocytes and endothelial cells. Expression of gene modules associated with blood-brain barrier (BBB) dysfunction was significantly enriched in FTD-GRN endothelial cells. The vasculature supportive function and capillary coverage by pericytes was reduced in FTD-GRN tissue, with increased and hypertrophic vascularization and an enrichment of perivascular T cells. Our results indicate a perturbed BBB and suggest that the neurovascular unit is severely affected in FTD-GRN.
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