Withdrawal: Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2.

VOLUME 281 (2006) PAGES 15605–15614 This article has been withdrawn by the authors. The actin panels for siHDAC2-I and siHDAC2-IV in Fig. 7E were duplicated. Additionally, in Fig. 7E, a portion of the HDAC2 gel from siHDAC2-II was duplicated in siHDAC2-III and siHDAC2-IV. Orphan Nuclear Receptor Nur77 Induces Zinc Finger Protein GIOT-1 Gene Expression, and GIOT-1 Acts as a Novel Corepressor of Orphan Nuclear Receptor SF-1 via Recruitment of HDAC2Journal of Biological ChemistryVol. 281Issue 23PreviewKruppel-associated box (KRAB) domain-containing proteins consist of potential transcriptional repression modules. Previously, gonadotropin-inducible ovarian transcription factor-1 (GIOT-1) was identified as a novel KRAB-containing zinc finger protein and shown to have transcriptional repression activity. Here, we demonstrate that orphan nuclear receptor Nur77 regulates GIOT-1 gene expression in testicular Leydig cell lines and that GIOT-1 acts as a novel corepressor of the orphan nuclear receptor steroidogenic factor 1 (SF-1). Full-Text PDF Open Access