Microspheres are small free-flowing particles with 1-1000um diameter and can be used to overcome the problems of conventional drug delivery. By altering the materials, methods, and polymers the therapeutic efficacy of microspheres containing drug content can be altered. We have discussed about microspheres, their various types, techniques used to manufacture microspheres, also about the advantages and different application of microsphere. Microspheres are used in novel drug delivery system. The microsphere will be assessed using a variety of procedures to determine its quality. Microspheres will play an important role in the delivery of novel medication in the future. Microspheres use in treatment of different disease conditions.