Single-Atom Nanozyme In this cover image, Fe-, Cu-, and Mn-based single-atom nanozymes are depicted as essential elemental messengers delivered by white birds to an injured cardiac landscape. Their arrival clears oxidative stress, reprograms inflammation, promotes angiogenesis, and restores vitality to infarcted myocardium, symbolizing a biomimetic strategy that transforms a damaged heart into a regenerating, functional tissue environment. More details can be found in the Research Article by Fangxi Xie, Junnan Tang, Xiaolin Cui and co-workers (DOI: 10.1002/adhm.202505365).