医学
精氨酸
甲基化
PCSK9
主动脉瓣
钙化
内科学
机制(生物学)
内分泌学
循环系统
DNA甲基化
主动脉
心脏病学
主动脉瓣狭窄
疾病
下调和上调
心脏瓣膜
受体
癌症研究
胆固醇
作者
Xi Zhang,Yanglin Hao,Dong Han,Xin Jin,Xiaoke Shang,Li Zhang,Zheng Gan,Weicong Ye,Song Wang,Xiaohan Li,Ran Li,Kexiao Zheng,Yinghuan Liu,Zifeng Zou,Zetong Tao,Yilong Li,Yongjun Wang,Jiahong Xia,Jie Wu
出处
期刊:Circulation
[Lippincott Williams & Wilkins]
日期:2026-03-09
标识
DOI:10.1161/circulationaha.125.078830
摘要
We identify a previously unrecognized posttranslational mechanism regulating PCSK9 stability in valve interstitial cells during calcific aortic valve disease and establish a link between PRMT3-mediated arginine methylation and valve-specific lipid-osteogenic coupling.
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