Efficacy of an artificial intelligence system for lesion detection and characterization ( CADe and CADx ) during colonoscopy following positive faecal immunochemical test in a colorectal cancer screening programme: A randomized clinical trial

In FIT-positive diagnostic colonoscopies with high baseline ADRs, AI assistance did not significantly improve lesion detection. Its primary utility lies in optimizing optical characterization by increasing specificity and PPV, suggesting a potential role in reducing false positives. Further multicentre studies incorporating cost-effectiveness analyses are warranted (ClinicalTrials.gov NCT07125300).