Protective Effects of Silymarin Co-Administered with CCl4 on Hepatotoxicity and Its Impact on Liver enzymes and Lipid Profile

This study explained the protective effects of silymarin against liver toxicity induced by carbon tetrachloride (CCl4) in female rats. Silymarin, a natural herbal compound extracted from the Milk thistle (Silybum marianum) plant, possesses well-documented antioxidant, anti-inflammatory, and anti-fibrotic properties. In the conducted experiment, rats that received silymarin alongside CCl4 exhibited significant improvements in liver enzyme (ALT, AST, ALP, and GGT) levels and lipid profiles (Total Cholesterol (TC), Triglycerides (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), and Very Low-Density Lipoprotein (VLDL) compared to those treated only with CCl4. These findings indicate that silymarin may serve as a potential preventive option for reducing liver damage caused by CCl4. Additional research is needed to comprehensively understand silymarin's impact on lipid metabolism and liver injury.