Magnetic Field‐Driven Electrogenic Scaffold Enhances the Nerve Regeneration

BACKGROUND: Neural conduits (NGCs) are widely used for peripheral nerve regeneration but have shown limited therapeutic effects. Electrical stimulation combined with NGCs is becoming a new treatment paradigm. Conventional electrical stimulation approaches for nerve regeneration are typically hindered by inconvenience, infection, and may cause secondary damage. METHODS: This study developed a non-contact electrical stimulation platform using a magnetic field-coupled polycaprolactone/conductive polymer poly(3,4-ethylenedioxythiophene)/black phosphorus nerve conduit. This composite nerve conduit exhibited excellent electrical properties and biocompatibility. When placed in an external rotating magnetic field, it was able to transmit pulsed currents into the targeted sites due to electromagnetic induction. RESULTS: The regeneration levels achieved with the magnetic field-driven nerve conduit were comparable to those of autologous transplantation. Immunofluorescence and histochemistry results demonstrated that this magnetic field-driven nerve conduit enhances axonal regeneration, neovascularization, and inflammation regulation. CONCLUSION: This work opens a new avenue for low-invasive and high-security bioelectronic therapy for long-segment peripheral nerve defects, with potential applications in various tissue regeneration engineering.