Unravelling tandem repeat-mediated mutagenesis drive rapid diversification of KPC enzymes: emergence of blaKPC-263 and enhanced resistance to ceftazidime-avibactam

This work was funded by the National Key R&D Programme of China (2023YFC2308400); National Natural Science Foundation of China (82072314); Shandong Provincial Laboratory Project (SYS202202); Zhejiang Province Leading Geese Plan (2025C04013); Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program (Grant No. 2017ZZ012); Zhejiang Provincial Medical and Health Science and Technology Project (2022KY355 &2024KY402) and Fundamental Research Funds for the Central Universities (2022ZFJH003).