Regenerative treatment of zinc-based nanoenzyme incorporated injectable hydrogel with mesenchymal stem cells alleviates spinal cord injury

forming thermoresponsive hydrogels (ZnNZ-HGL) that facilitate dual improvement of MSCs paracrine and viability effects, resulting in highly effective spinal cord reconstruction. The sol-gel transitions characteristic of ZnNZ-HGL at the physiological milieu guarantees consistent distribution of HGL in damaged spinal cord tissue. Our findings indicate that ZnNZ-HGL markedly enhances the survivability of MSCs within the milieu by mitigating oxidative stress (OS) and, crucially, stimulates the release of MSCs' angiogenic factors. The interplay among the oxidative stress-mitigating properties of ZnNZs influence of MSC enhances nerve healing, angiogenesis, and functional recovery following SCI, presenting a promising approach for MSCs-derived SCI treatment.