医学
结直肠癌
肿瘤科
癌症
单克隆抗体
临床试验
转移
内科学
曲妥珠单抗
表皮生长因子受体
酪氨酸激酶
癌症研究
抗体
受体
免疫学
乳腺癌
作者
Binbin Zheng-Lin,Tanios Bekaii‐Saab
标识
DOI:10.1177/17588359231225037
摘要
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Approximately 3–5% of colorectal tumors harbor human epidermal growth factor receptor ( HER2) amplification which is associated with a higher incidence of intracranial metastasis and overall worse outcomes. In the setting of refractory metastatic RAS wild-type tumors, evidence supports the use of various HER2-blocking agents, including monoclonal antibodies, tyrosine kinase inhibitors, and novel antibody–drug conjugates. With a number of relatively active agents clinically available and even more in development, it is crucial for clinicians to familiarize themselves with the mechanisms of action, efficacy data, and safety profiles of these treatments. In this review, we aim to summarize key findings from past and ongoing trials with anti-HER2 agents in metastatic colorectal cancer.
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