热疗
磁热疗
癌症治疗
磁性纳米粒子
纳米技术
材料科学
癌症治疗
纳米颗粒
铁氧体(磁铁)
生化工程
医学
癌症
内科学
工程类
复合材料
作者
Linxue Zhang,Qifan Li,Junxiao Liu,Zun‐Yi Deng,Xueliang Zhang,Nuernisha Alifu,Xiaofeng Zhang,Zhong Yu,Yu Liu,Zhongwen Lan,Tianlong Wen,K. Sun
标识
DOI:10.1016/j.colsurfb.2024.113754
摘要
Cancers are fatal diseases that lead to most death of human beings, which urgently require effective treatments methods. Hyperthermia therapy employs magnetic nanoparticles (MNPs) as heating medium under external alternating magnetic field. Among various MNPs, ferrite nanoparticles (FNPs) have gained significant attention for hyperthermia therapy due to their exceptional magnetic properties, high stability, favorable biological compatibility, and low toxicity. The utilization of FNPs holds immense potential for enhancing the effectiveness of hyperthermia therapy. The main hurdle for hyperthermia treatment includes optimizing the heat generation capacity of FNPs and controlling the local temperature of tumor region. This review aims to comprehensively evaluate the magnetic hyperthermia treatment (MHT) of FNPs, which is accomplished by elucidating the underlying mechanism of heat generation and identifying influential factors. Based upon fundamental understanding of hyperthermia of FNPs, valuable insights will be provided for developing efficient nanoplatforms with enhanced accuracy and magnetothermal properties. Additionally, we will also survey current research focuses on modulating FNPs' properties, external conditions for MHT, novel technical methods, and recent clinical findings. Finally, current challenges in MHT with FNPs will be discussed while prospecting future directions.
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