纳米医学
背景(考古学)
癌症治疗
癌症
癌症治疗
纳米技术
癌细胞
癌症研究
医学
生物
纳米颗粒
材料科学
内科学
古生物学
作者
Soghra Farzipour,Fatemeh Jalali Zefrei,Saeed Bahadorikhalili,Maryam Alvandi,Arsalan Salari,Zahra Shaghaghi
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2024-01-24
卷期号:24
标识
DOI:10.2174/0118715206278427231215111526
摘要
Abstract: Current cancer treatment options have presented numerous challenges in terms of reaching high efficacy. As a result, an immediate step must be taken to create novel therapies that can achieve more than satisfying outcomes in the fight against tumors. Ferroptosis, an emerging form of regulated cell death (RCD) that is reliant on iron and reactive oxygen species, has garnered significant attention in the field of cancer therapy. Ferroptosis has been reported to be induced by a variety of small molecule compounds known as ferroptosis inducers (FINs), as well as several licensed chemotherapy medicines. These compounds' low solubility, systemic toxicity, and limited capacity to target tumors are some of the significant limitations that have hindered their clinical effectiveness. A novel cancer therapy paradigm has been created by the hypothesis that ferroptosis induced by nanoparticles has superior preclinical properties to that induced by small drugs and can overcome apoptosis resistance. Knowing the different ideas behind the preparation of nanomaterials that target ferroptosis can be very helpful in generating new ideas. Simultaneously, more improvement in nanomaterial design is needed to make them appropriate for therapeutic treatment. This paper first discusses the fundamentals of nanomedicine-based ferroptosis to highlight the potential and characteristics of ferroptosis in the context of cancer treatment. The latest study on nanomedicine applications for ferroptosis-based anticancer therapy is then highlighted.
科研通智能强力驱动
Strongly Powered by AbleSci AI