细胞周期蛋白依赖激酶6
乳腺癌
癌症研究
细胞周期
肿瘤科
癌症
医学
内科学
计算生物学
药理学
生物信息学
生物
细胞周期蛋白依赖激酶
作者
Zeenat Khatoon,Mohammad Khalid,Mohammed H. Alqarni,Ahmed I. Foudah,Sivakumar Annadurai,Shadma Wahab,Mohammad Ali Abdullah Almoyad
标识
DOI:10.1080/07391102.2023.2294375
摘要
CDK6 is a critical protein involved in the regulation of the cell cycle, playing an important role in the progression from the G1 to S phase. In breast cancer, dysregulation of this protein is involved in tumour development and progression, particularly in hormone receptor-positive (HR+) breast cancers. The upregulation of CDK6 have been observed in a subset of breast cancers, leading to uncontrolled progression of the cell cycle and increased proliferation of cells. The purpose of this abstract is to provide an outline of CDK6's role. In breast cancer and the therapeutic strategies targeting CDK6 using specific selected inhibitors. To discover viable therapeutic candidates after competitive inhibition of CDK6 with a small molecular drug complex, high throughput screening and docking studies were used. Further, we carried the compounds based on ADMET properties and prediction of activity spectra for substances analysis. Finally, two different compounds were selected to carry out MD simulations. CDK6-IMPHY002642 and CDK6-IMPHY005260 are the two compounds that were identified. Overall, our results suggest that the CDK6-IMPHY002642 and CDK6-IMPHY005260 complex was relatively stable during the simulation. The compounds that have been found can also be further examined as potential therapeutic possibilities. The combined findings suggest that CDK6, together with their genetic changes, can be investigated in therapeutic interventions for precision oncology, leveraging early diagnostics and target-driven therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI