整合素
癌症研究
信号转导
转移
上皮-间质转换
转化生长因子β
癌症
细胞生长
细胞粘附
生物
阿尔法(金融)
癌细胞
医学
细胞生物学
细胞
生物信息学
内科学
生物化学
护理部
结构效度
患者满意度
作者
Ewa Brzozowska,Sameer Deshmukh
标识
DOI:10.3390/ijms232012346
摘要
Integrins are necessary for cell adhesion, migration, and positioning. Essential for inducing signalling events for cell survival, proliferation, and differentiation, they also trigger a variety of signal transduction pathways involved in mediating invasion, metastasis, and squamous-cell carcinoma. Several recent studies have demonstrated that the up- and down-regulation of the expression of αv and other integrins can be a potent marker of malignant diseases and patient prognosis. This review focuses on an arginine-glycine-aspartic acid (RGD)-dependent integrin αVβ6, its biology, and its role in healthy humans. We examine the implications of αVβ6 in cancer progression and the promotion of epithelial-mesenchymal transition (EMT) by contributing to the activation of transforming growth factor beta TGF-β. Although αvβ6 is crucial for proper function in healthy people, it has also been validated as a target for cancer treatment. This review briefly considers aspects of targeting αVβ6 in the clinic via different therapeutic modalities.
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