Associations between short-term exposure to ambient PM 2.5 and incident cases of cardiovascular disease in Yantai, China

ABSTRACTThere are limited studies investigating the association between short-term exposure to PM2.5 and incident cardiovascular disease (CVD) cases in China. This study aims to examine the short-term effects of PM2.5 on the incidence of cardiovascular diseases. A combination of Poisson-distribution generalized linear model and distributed lag non-linear model was used to examine the association between short-term exposure to PM2.5 and incident cases of CVD. The results revealed that per 10 µg/m3 increment of PM2.5 would increase the incident CVD cases by 0.147% (Relative Risk: 1.00147, 95% Confidence Interval: 1.00008–1.00286) at a lag of 2 days. The stratified analyses showed higher effects risk in females, older residents (aged 60–75 years), and acute myocardial infarction group (p-value for difference <0.05). This study indicates that short-term exposure to PM2.5 may increase the risk of CVD and highlights the necessity for a higher air quality standard in Yantai, China.KEYWORDS: Air pollutioncardiovascular diseaseincident casesPM2.5generalized linear model AcknowledgmentsThanks to the Disease Control and Prevention Center of Yantai for providing the cardiovascular disease cases data.Author's contributionCH, GW, and YZ designed the study. JL and HC drafted the manuscript. JL, HS, HC, HL, YS, and LW performed the data analysis. CH and YZ edited the manuscript. JL and HL drew the figures. All authors commented on the draft and revised version of the paper and approved the submission texts.Availability of data and materialsThe data that support the findings of this study are available upon request from the authors.Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingCH was supported by Shandong Province social science planning research project (22CRKJ01).