间充质干细胞
纳米颗粒
药物输送
体内
渗透
渗透(战争)
纳米技术
化学
胶体金
生物医学工程
材料科学
生物物理学
癌症研究
医学
病理
生物化学
膜
生物技术
工程类
生物
运筹学
作者
Lining Xu,Ming Xu,Xing Sun,Neus Feliu,Liuxing Feng,Wolfgang J. Parak,Sijin Liu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-01-30
卷期号:17 (3): 2039-2052
被引量:18
标识
DOI:10.1021/acsnano.2c07295
摘要
There are still some gaps in existing knowledge in the field of cancer nanotheranostics, e.g., the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold nanoparticles (Au NPs) were delivered to tumors in both subcutaneous tumor and lung metastasis tumor models by intravenous injection of either free Au NPs or of human bone marrow mesenchymal stem cells (MSCs), which were loaded with endocytosed Au NPs. By making injections with the same dose of administrated Au NPs, it was possible to directly compare tumor targeting of both delivery modes. Hereby, the passive targeting of tumor by the plain Au NPs was facilitated by the enhanced permeation and retention (EPR) effect. Au NP retention by tumors, as well as tumor penetration, were found to be improved up to 2.4-to-9.3-fold when comparing the MSC-mediated delivery of Au NPs to the delivery of the plain Au NPs via EPR effect on day 7 post administration. While the absolute retention of Au NPs in the tumor remained low, our data show that, upon injection of the same amount of Au NPs, in fact MSC-mediated delivery is quantitatively higher than EPR-mediated delivery of NPs by half an order of magnitude.
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