Endothelin receptor B is Required for the Blood Pressure lowering Effect of G Protein-coupled Estrogen Receptor 1 in Ovariectomized Rats.

Activation of G protein-coupled estrogen receptor 1 (GPER1) elicits antihypertensive actions in different animal models. The endothelin-1 signaling system plays a fundamental role in blood pressure regulation. Lack of functional endothelin receptor B (ET