DLX6‐AS1 regulates odonto/osteogenic differentiation in dental pulp cells under the control of BMP9 via the miR‐128‐3p/MAPK14 axis: A laboratory investigation
化学
细胞生物学
牙髓(牙)
生物
牙科
医学
作者
Liu Liu,Tongfeng Fang,Cheng Miao,Xiangfen Li,Yanglin Zeng,Tianyi Wang,Yubin Cao,Dingming Huang,Dongzhe Song
The regenerative capacity of dental pulp relies on the odonto/osteogenic differentiation of dental pulp cells (DPCs), but dynamic microenvironmental changes hinder the process. Bone morphogenetic protein 9 (BMP9) promotes differentiation of DPCs towards an odonto/osteogenic lineage, forming dentinal-like tissue. However, the molecular mechanism underlying its action remains unclear. This study investigates the role of DLX6 antisense RNA 1 (DLX6-AS1) in odonto/osteogenic differentiation induced by BMP9.